Worried About Dementia? You Might Want to Check Your Blood Pressure
Meningitis changes immune cell makeup in the mouse brain lining
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Our brains may ripple before remembering
Understanding Aging Brain Disorders
Neuroligins
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Worried About Dementia? You Might Want to Check Your Blood Pressure

Dr. Walter Koroshetz was recently featured on National Public Radio (NPR) with a story on the link between high blood pressure and dementia. In 2016, at Dr. Koroshetz’s urging, OCPL designed and launched the Mind Your Risks® public education campaign to raise awareness about the importance of controlling blood pressure in midlife to help reduce the risk of having a stroke and possibly developing dementia later in life. Since its launch, Mind Your Risks has reached a wide audience with this important message.We are thrilled that Dr. Koroshetz had the opportunity to amplify NINDS research and education programs on NPR on Monday.    Learn More » Exit Disclaimer

Meningitis Changes Immune Cell Makeup in the Mouse Brain Lining

Meningitis, a group of serious diseases which infect the brain’s lining, leaves its mark and can affect the body’s ability to fight such infections in the future. According to a new study published in Nature Immunology by Dr. Dorian McGavern, infections can have long-lasting effects on a population of meningeal immune cells, replacing them with cells from outside the meninges that then change and become less likely to recognize and ward off future attacks. The research was supported by the NINDS, part of the National Institutes of Health.   Learn More » Exit Disclaimer

Severing Enzymes Amplify Microtubule Arrays Through Lattice GTP-tubulin Incorporation

Dr. Antonina Roll-Mecak's laboratory recently published a paper in Science that shows active repair of microtubules by two enzymes involved in hereditary spastic paraplegias and microcephaly. This repair reinforces microtubules and allows microtubule arrays to rapidly amplify. The illustration  was featured in the front matter of the Science issue in which the publication appeared. Learn More » Exit Disclaimer

Our Brains May Ripple Before Remembering

A sound, a smell, a word can all flood our minds with memories of past experiences. In a study of epilepsy patients led by Dr. Kareem Zaghloul, researchers at the National Institutes of Health found that split seconds before we recall these events tiny electrical waves, called ripples, may flow through key parts of our brains that help store our memories, setting the stage for successful retrieval. Learn More » Exit Disclaimer

NIH Study Implicates Hyperactive Immune System in Aging Brain Disorders

In a study of fruit flies, NIH scientists suggested that the body’s immune system may play a critical role in the damage caused by aging brain disorders. The results are based on experiments in which the researchers altered the activity of Cdk5, a gene that preclinical studies have suggested is important for early brain development and may be involved in neurodegenerative diseases, such as ALS, Alzheimer’s and Parkinson’s disease. Previously, they found that altering Cdk5 sped up the genetic aging process, causing the flies to die earlier than normal and have problems with walking or flying late in life and greater signs of neurodegenerative brain damage.  Learn More » 

Isoform-specific Cleavage of Neuroligin-3 Reduces Synapse Strength

Neuroligins are neuronal cell adhesion molecules that have been associated with autism spectrum disorders. However, recent reports have identified a cleaved form of Neuroligin-3 (NLGN3) as a potent mitogen, which promotes glioma growth. A publication of a new study led by Dr. Katherine Roche demonstrates that NLGN3 is proteolytically cleaved in response to synaptic activity and protein kinase C signaling resulting in reduced synapse strength. These findings show an unexpected neuronal role for neuroligins in synapse disassembly. In addition, these mechanistic insights into NLGN3 cleavage could aid in developing novel therapeutic targets for glioma.  Learn More »